The three-year collaboration brings together a patented plant-breeding technology called MemoGene, developed by Israel’s Danziger Innovations and the Hebrew University’s Yissum tech-transfer company, with a DNA editing platform developed by Precision Biosciences in North Carolina.
The platform’s biological “scissors”will be tailored to cut open the
flower’s genome at exactly the right spot for MemoGene to deliver the
life-extending trait.
“It’s a perfect symbiosis, because we each have a piece of a two-piece puzzle,” says Hanne Volpin, deputy CEO and head of R&D at Danziger Innovations. “We have the technology to deliver tools to make the modification to the genome, while Precision Biosciences owns the IP for the biological scissors that cut the genome.”
The partnership is supported by a grant from the BIRD (Israel-U.S. Binational Industrial Research and Development) Foundation warded in December last year.
“This new technology enables and democratizes the process of crop perfection, because until now only very large corporations like Monsanto were active in this area,” says BIRD Director of Business Development Ron Maron.
“Now, smaller companies and even university startups can get into this field and offer quicker and cheaper new traits to plant breeders.”
It’s fitting that the petunia project has an Israeli partner. “Plant breeding started in the Middle East and a few other places about 8,000 years ago, and we’re continuing the tradition,” Maron points out.
Precise breeding
Volpin explains that “domesticating” plants for the market by selecting genes to enhance yield and seed quality causes some desirable traits to be lost along with undesirable ones. Reinserting the lost “good” trait is a cumbersome, lengthy process that can be shortened by using GMO genetic modification – a technique that is highly regulated because it raises questions of safety in food crops.
“Our [genetic engineering] technology is as specific as GMO, but it’s deregulated because we’re not adding any new genes you wouldn’t find in nature,” says Volpin. This advantage hastens commercialization and avoids consumer concerns.
Though the technology can be applied to just about any crop – and probably will be in the future – petunias were a good place to start. The pink-to-purple flower is a favorite; 300 million to 350 million cuttings are supplied to growers around the world every year. And the flower is well understood on a molecular level due to numerous scientific studies.
Another reason to start with petunias is Danziger’s expertise and market share in petunia varieties. The family-owned Danziger Innovations, founded in 2008, is the R&D spinoff of the 62-year-old Danziger Dan Flower Farm, one of the world’s top five providers of petunia cuttings.
“Our petunias are propagated by cuttings, not by seeds,” explains Yael Matar, in charge of Danziger’s business development. “We export our propagating material from Israel to growers and nurseries all over the world.”
Located in Mishmar HaShiv’a near Ben-Gurion International Airport, Danziger Dan Flower Farm is one of biggest floriculture breeders and exporters in Israel, supplying not only petunia cuttings but also propagating material for many ornamental plants and flowers to customers in 60 countries.
The innovative petunias coming from the new joint project are to be tested and implemented in Israel as well as in Danziger-owned flower farms in Guatemala and Kenya, where land and water are more plentiful than in Israel.
Courtesy: ISRAEL21c
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